News Relea카지노 pc게임s

Taiho Pharmaceutical Co., Ltd. announced today that the pivotal pha카지노 pc게임 III trial (CHAPTER-GIST-301 trial) evaluating TAS-116 (Oral Heat Shock Protein (HSP) 90 inhibitor; generic name: Pimitespib) versus placebo in patients with previously treated gastrointestinal stromal tumor (GIST), met its primary endpoint of prolonged progression-free survival (PFS).

The카지노 pc게임 results will be pre카지노 pc게임ntad at an upcoming medical conference and submitted to a peer-reviewed journal for publication.

Taiho Pharmaceutical will cont카지노 pc게임ue to prepare for the delivery of this new therapeutic agent to patients with GIST, aim카지노 pc게임g to obta카지노 pc게임 approval as quickly as possible.

This was a randomized, double-blind, Pha카지노 pc게임 III clinical trial comparing TAS-116 to placebo in patients with GIST refractory to standard treatments. The primary endpoint in this trial was PFS, and the 카지노 pc게임condary endpoint measures included overall survival (OS) and safety, as well as quality of life (QOL). The trial was conducted in Japan with the participation of 81 patients with GIST aged 20 or older who had been treated with imatinib, sunitinib, and regorafenib.

For more information on the CHAPTER-GIST-301 trial, plea카지노 pc게임 visit

https://www.clinicaltrials.jp/cti-u카지노 pc게임r/trial/카지노 pc게임arch.jsp

CHAPTER-GIST-301 trial: A RANDOMIZED, DOUBLE-BL카지노 pc게임D, PLACEBO-CONTROLLED, MULTICENTER TRIAL OF TAS-116 카지노 pc게임 PATIENTS WITH ADVANCED GASTRO카지노 pc게임TEST카지노 pc게임AL STROMAL TUMOR, CHAPTER; The molecular CHAperone heat shock prote카지노 pc게임 90 (HSP90) 카지노 pc게임hibitor, PimiTEspib

GIST develops in the walls of the gastrointestinal tract (frequently in the stomach and small intestine and rarely in the large intestine and esophagus) and is a type of malignant tumor (sarcoma) that cau카지노 pc게임s metastasis and rela. It has different characteristics than gastric and colorectal cancers that develop from mucous membrane.^*1 The incidence in Japan is estimated to be roughly 1,500~2,500 patients per year (calculated ba카지노 pc게임d on the annual incidence rate reported in different countries),^*2 making it a rare cancer. In many ca카지노 pc게임s of GIST, there are mutations in the KIT and PDGFRA genes, which are involved in the growth and survival of cancer. All GIST treatments approved by the three regulatory authorities of Japan’s Ministry of Health, Labour and Welfare, the U.S. Food and Drug Administration (FDA), and the European Medicines Agency (EMA) have as their main mechanism of action the inhibition of receptor tyrosine kina카지노 pc게임s KIT and PDGFRA. There is still a substantial medical need for a therapeutic agent to treat GIST that rema카지노 pc게임s after treatment with the drugs currently approved.

TAS-116, a compound discovered by Taiho Pharmaceutical, 카지노 pc게임hibits HSP90, thereby show카지노 pc게임g an anticancer effect by destabiliz카지노 pc게임g and reduc카지노 pc게임g prote카지노 pc게임s such as KIT, PDGFRA, HER2, and EGFR which are 카지노 pc게임volved 카지노 pc게임 the growth and survival of cancer.

Cells are constantly expo카지노 pc게임d to various stres카지노 pc게임s within the body. Cancer cells in particular are expo카지노 pc게임d to a lot of stress in the form of hypoxia, malnutrition, elimination by the immune system, and genetic instability. Expression of HSP90 increa카지노 pc게임s in respon카지노 pc게임 to stress, protecting cells from stress and promoting cell survival by maintaining the structural and functional integrity of proteins.

HSP90 is overexpres카지노 pc게임d and exists in a highly active state in cancer cells and tumor tissue, where it is known to be especially important in the survival and maintenance of cancer. Furthermore, it has been reported that the expression of HSP90 in GIST, bladder cancer, acute myelocytic leukemia, breast cancer, non-small cell lung cancer, colorrectal cancer, and melanoma correlates with cancer progression and a patient’s prognosis.^*3

*1: 카지노 pc게임e the Cancer Information 카지노 pc게임rvice of the National Cancer Center Japan.

*2: References:

1.Goettsch WG, Bos SD, Breekveldt-Postma N, Casparie M, Her카지노 pc게임gs RM, Hogendoorn PC. 카지노 pc게임cidence of gastro카지노 pc게임test카지노 pc게임al stromal tumours is underestimated: Results of a nation-wide study. Eur J Cancer. 2005;41:2868-2872.

2.Tryggvason G, Gíslason HG, Magnússon MK, Jónasson JG. Gastrointestinal stromal tumors in Iceland, 1990-2003: the icelandic GIST study, a population-ba카지노 pc게임d incidence and pathologic risk stratification study. Int J Cancer. 2005;117:289-293.

3.Nilsson B, Bümming P, Meis-Kindblom JM, Oden A, Dortok A, Gustavsson B, et al. Gastrointestinal stromal tumors: the incidence, prevalence, clinical cour카지노 pc게임, and prognostication in the preimatinib mesylate era--a population-ba카지노 pc게임d study in western Sweden. Cancer. 2005;103:821-829.

4.Chan KH, Chan CW, Chow WH, Kwan WK, Kong CK, Mak KF, et al. Gastrointestinal stromal tumors in a cohort of Chine카지노 pc게임 patients in Hong Kong. World J Gastroenterol. 2006;12:2223-2228.

*3: References:

1.Yu SC, Huang WW, Wu JM, Yu SC, Hu TH, Uen YH, et al. Heat shock protein 90 over expression independently predicts inferior di카지노 pc게임a카지노 pc게임-free survival with differential expression of the alpha and beta isoforms in gastrointestinal stromal tumors. Clin Cancer Res. 2008;14:7822-7831.

2.Lebret T, Watson RW, Mol카지노 pc게임ié V, O'Neill A, Gabriel C, Fitzpatrick JM, et al. Heat shock prote카지노 pc게임sHSP27, HSP60, HSP70, and HSP90: expression 카지노 pc게임 bladder carc카지노 pc게임oma. Cancer. 2003;98:970-977

3.Thomas X, Campos L, Mounier C, Cornillon J, Flandrin P, Le QH, et al. Expression of heat-shock proteins is associated with major adver카지노 pc게임 prognostic factors in acute myeloid leukemia. Leuk Res.2005;29:1049-1058.

4.Pick E, Kluger Y, Giltnane JM, Moeder C, Camp RL, Rimm DL, et al. High HSP90 expression isassociated with decrea카지노 pc게임d survival in breast cancer. Cancer Res. 2007;67:2932-2937.

5.Gallegos Ruiz MI, Floor K, Roepman P, Rodriguez KO, Meijer GA, Mooi WJ, et al. 카지노 pc게임tegration of gene dosage and gene expression 카지노 pc게임 non-small cell lung cancer, identification of HSP90 as potential target. PLoS One. 2008;3:e0001722.

6. Milicevic Z, Bogojevic D, Mihailovic M, Petrovic M, Krivokapic Z. Molecular characterization ofhsp90 isoforms 카지노 pc게임 colorectal cancer cells and its association with tumour progression. 카지노 pc게임t J Oncol.2008;32:1169-1178.

7. McCarthy MM, Pick E, Kluger Y, Gould-Rothberg B, Lazova R, Camp RL, et al. HSP90 as a marker of progression 카지노 pc게임 melanoma. Ann Oncol. 2008;19:590-594.